Studies on the Vaginal Microbiome
Is there a protective role for vaginal flora?
Jack D. Sobel. Current Infectious Disease Reports (1999)
​
An early review of the vaginal microbiome by a leader in vaginal dysbiosis clinical research describing the beneficial effects of a lactobacilli-dominant vaginal microbiome.
​
​
A New Era of the Vaginal Microbiome: Advances Using Next Generation Sequencing
Jennifer M. Fettweis, Myrna G. Serrano, Philippe H. Girerd, Kimberly K. Jefferson, and Gregory A. Buck. Chemistry and Biodiversity (2012)
​
A newer molecular biology tool called next-generation sequencing has led to giant steps forward in our understanding of the vaginal microbiome compared with what old microbiological culture techniques allowed.
​
​
Analysis of the Vaginal Microbiome by Next-Generation Sequencing and Evaluation of its Performance as a Clinical Diagnostic Tool in Vaginitis
Ki Ho Hong, Sung Kuk Hong, Sung Im Cho, Eunkyung Ra, Kyung Hee Han, Soon Beom Kang, Eui-Chong Kim, Sung Sup Park, and Moon-Woo Seong. Annals of Laboratory Medicine (2016)
​
Next-generation sequencing may become a useful clinical tool for diagnosing vaginal conditions, but it is not ready for prime time as of the date of publication.
​
​
Vaginal Microbiome in Women from Greenland Assessed by Microscopy and Quantitative PCR
Raluca Datcu, Dionne Gesink, Gert Mulvad, et al. BMC Infectious Diseases (2013).
​
Bacterial vaginosis is highly prevalent in Greenland: 45% of women tested had BV as assessed by Nugent score, which correlated well with PCR testing.
​
​
Pathogenesis of abnormal vaginal bacterial flora
Gilbert G. G. Donders, Eugene Bosmans, Alfons Dekeersmaecker, Annie Vereecken, Ben Van Bulck, and Bernard Spitz. American Journal of Obstetrics and Gynecology (2000)
​
A primary research article revealing a relationship between dysbiosis and inflammation as determined by wet mount microscopy and immune system activation as assessed by levels of cytokines IL-1beta, IL-8, leukemia inhibitory factor, and IL-1 receptor antagonist.
​
​
Vaginal Microbiota
Werner Mendling. Microbiota of the Human Body (2016)
​
This book chapter summarizes current understanding of the composition of healthy and unhealthy (bacterial vaginosis, aerobic vaginitis) vaginal microbiomes, and discusses the role of lactobacillus probiotics in restoring health.
​
​
​